艰难梭菌的研究进展

Progress in studies on Clostridium difficile

艰难梭菌为革兰阳性厌氧芽胞杆菌,可引起艰难梭菌相关性腹泻,导致一系列肠道感染症状和相关临床表现。近年来由于高致病株的出现、菌株耐药性的增加,艰难梭菌感染在全球呈蔓延趋势。本文就艰难梭菌的耐药机制、检测技术、防治及国内感染现状等作一简要综述。

Clostridium difficile is gram-positive anaerobic bacillus,which can cause Clostridium difficile-associated diarrhea,and lead to a series of intestinal infection symptoms and associated clinical manifestations.In recent years,the prevalence and severity of CDI has increased,The rising rates of CDI have largely been attributed to the strains resistant to metronidazole or vancomycin,and the emergence of hypervirulent strain.This paper presents a brief review on Clostridium difficile,concerning its isolation and culture,biological characteristics,pathogenesis and drug resistance mechanisms,clinical manifestations and detection techniques,prevention,domestic infection status and other advances.