乙型肝炎患者多项血清白介素及NO、CRP、TNF-α、D-D水平变化研究

Study on changes of levels of serum interleukins,NO,CRP,TNF-α and D-D in hepatitis B patients

目的探讨乙型肝炎患者多项血清白介素及及一氧化氮(NO)、C-反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、D-二聚体(D-D)水平变化。方法选择医院2009年6月-2011年5月就诊的150例乙型肝炎患者作为研究对象并视为观察组,并选择同期于医院健康体检者148例作为对照组,观察乙型肝炎患者的多项血清白介素(IL-2、IL-10、IL-12)及NO、CRP、TNF-α、D-D水平变化。结果观察组患者的血清IL-2和IL-10分别为(13.78±1.06)μg/L、(22.47±1.96)μg/L,均明显高于对照组(均P<0.05),而血清IL-12水平低下、为(31.63±3.40)pg/ml;观察组患者血清NO、CRP、TNF-α、D-D分别为(91.86±27.60)μmol/L、(6.25±1.14)mg/L、(35.00±10.00)pg/ml、(0.67±0.20)μg/ml,与对照组比较均明显升高,差异均有统计学意义(均P<0.05)。结论乙型肝炎患者多项血清白介素及NO、CRP、TNF-α、D-D水平变化明显,与病毒复制、肝细胞凋亡和坏死等存在一定的关联,可以为乙型肝炎的诊断、治疗提供可靠的临床依据。

OBJECTIVE To investigate the changes of serum interleukins,NO,CRP,TNF-α and D-D in hepatitis B patients.METHODS A total of 150 patients with hepatitis B admitted in our hospital from Jun.2009 to May 2011 were chosen as the research subjects and regarded as the observation group.One hundred and forty-eight healthy individuals receiving physical examination in our hospital during the same period were selected as the control group.The changes of serum interleukins（IL-2,IL-10 and IL-12）,NO,CRP,TNF-α and D-D in patients with hepatitis B were examined.RESULTS The serum IL-2 and IL-10 in the observation group were（13.78±1.06）μg/L and（22.47±1.96）μg/L,respectively,which were significantly higher than the control group（both P〈0.05）,while serum IL-12 level was low,i.e.（31.63±3.40）pg/ml.The levels of serum NO,CRP,TNF-αand DD in the observation group were（91.86±27.60）μmol/L,（6.25±1.14）mg/L,（35.00±10.00）pg/ml and（0.67±0.20）μg/ml respectively.Compared with the control group,all these factors were significantly higher and the differences were statistically significant（P〈0.05）.CONCLUSION The changes of serum interleukins,NO,CRP,TNF-α and D-D in patients with hepatitis B are significant,which have certain correlation with viral replication,apoptosis and necrosis of liver cells.These findings also provide a reliable basis for the clinical diagnosis and treatment of hepatitis B.