肠杆菌科细菌对头孢哌酮/舒巴坦的耐药性分析

Drug resistance of Enterobacteriaceae to cefoperazone/sulbactam

目的了解头孢哌酮/舒巴坦作用肠杆菌科细菌的耐药情况。方法对2010年1月-2011年2月医院临床分离的1280株肠杆菌科细菌进行头孢哌酮/舒巴坦药物敏感试验,并对结果进行分析。结果在临床分离的1280株肠杆菌科细菌中,主要为埃希菌属、克雷伯菌属、变形菌属、沙雷菌属,分别占60.2%、13.2%、12.0%、6.5%;埃希菌属对头孢哌酮/舒巴坦的耐药率为6.5%,克雷伯菌为14.8%,变形菌属为1.9%,肠杆菌属为13.0%,沙雷菌属为4.8%,柠檬酸杆菌属为17.4%,摩氏摩根菌及沙门菌属的耐药率均为0。结论头孢哌酮/舒巴坦可作为医院中重度感染的首选药物之一。

OBJECTIVE To investigate the drug resistance of Enterobacteriaceae isolates to cefoperazone/sulbactam.METHODS The drug susceptibility test of cefoperazone/sulbactam was performed for 1280 strains of Enterobacteriaceae isolated from Jan 2010 to Feb 2011,the result was analyzed.RESULTS Of 1280 strains of Enterobacteriaceae isolated,Escherichia spp,Klebsierlla spp,Proteus spp,and Serratia spp.were predominant pathogens,accounting for 60.2%,13.2%,12.0%,and 6.5%,respectively;the resistance rates of Escherichia spp,Klebsierlla spp,Proteus spp,Enterobacter spp,Serratia spp,and Citrobacter spp to cefoperazone/sulbactam were 6.5%,14.8%,1.9%,13.0%,4.8%,and 17.4%,respectively,the resistance rates of both Morgan spp and Salmonella spp were 0.CONCLUSION Cefoperazone/sulbactam can served as the preferred antibiotics for moderate and severe infections.