依达拉奉对糖尿病周围神经病变氧化应激和神经传导速度的影响

目的 观察依达拉奉对糖尿病周围神经病变（DPN）患者氧化应激状态和神经传导速度的影响,评价疗效.方法 40例DPN患者予依达拉奉60mg/d,静脉滴注2周,检测治疗前后氧化和抗氧化系统指标和神经传导速度,并进行总体症状评分（TSS）.结果 治疗后DPN患者血清一氧化氮（NO）、丙二醛（MDA）含量明显降低,超氧化物歧化酶（SOD）活力明显提高,运动神经传导速度（MCV）、感觉神经传导速度（SCV）显著增快,TSS评分明显下降,差异均有统计学意义（P＜0.01）.结论 依达拉奉可抑制DPN患者氧化应激,提高神经传导速度,改善临床症状.

Objective To observe the edaravone on oxidative stress and nerve conduction velocity in patients with diabetic peripheral neuropathie$. Methods 40 cases of patients with diabetic peripheral neuropathies were treated with edaravone 60rag daily intravenously for two weeks. Oxidative stress, nerve conduction velocity and total symptoms score were measured before and after the treatment. Results After edaravone treatment, there were significant decreac in NO and MDA level and increase in SOD activity （ P 〈 0. 01 ）. MCV and SCV were significant improved（P 〈0. 01 ）.There was significant decreae in TSS （P 〈0. 01 ）. Conclusions edaravone can inhibit the oxidative stress and improve MCV and SCV in patients with diabetic peripheral neuropathies, improve the clinical symptoms.