干扰素α-2b联合苦参素对慢性乙型肝炎患者T淋巴细胞亚群的影响

Effect of IFN α-2b combined with Oxymatrine on T-lymphocyte subsets in patients with chronic hepatitis B

目的研究干扰素α-2b联合苦参素对慢性乙型肝炎的临床疗效及对T淋巴细胞亚群的影响。方法将108例慢性乙型肝炎患者随机分为对照组和治疗组,对照组给予干扰素α-2b,治疗组在对照组的基础上给予苦参素,连续给药3个月,评价两组的临床疗效。结果治疗组患者HBV DNA转阴率、HBeAg转阴率及HBeAg/抗HBe血清转换率均高于对照组(P<0.05);治疗组治疗3个月后CD3+、CD4+细胞数和CD4+/CD8+比值较治疗前显著升高,与对照组比较差异有统计学意义(P<0.05)。结论干扰素α-2b联合苦参素可改善慢性乙型肝炎患者外周血T淋巴细胞亚群状态,具有确切的临床疗效,是一种可靠的治疗方案。

Objective To study the effect of IFN α-2b and Oxymatrine on T-lymphocyte subsets in patients with chronic hepatitis B. Methods All of 108 cases chronic hepatitis B were divided into control group and treatment group. The control group was given IFN α-2b, and the treatment group was given Oxymatrine for 3 months continuously on the basis of control group. The clinical effect was evaluated. Results The negative conversion rates of HBV DNA and HBeAg and HBeAg/ anti-HBe serconversion rate were significantly higher in the treatment group than in the control group （P 〈 0.05）. After 3 months, the percentages of CD3＋, CD4＋ and CD4＋/CD8＋ T-lymphocytes were significantly higher in the treatment group than in the control group （P 〈 0.05）. Conclusion IFN α-2b and Oxymatrine can improve efficacy and increase the percentages of T-lymphocytes in patients with chronic hepatitis B, and it is a reliable evidence for treatment of chronic hepatitis B.