缬沙坦联合卡托普利治疗原发性高血压的疗效观察

Efficacy of Valsartan combined with Captopril in treatment of primary hypertension

目的观察缬沙坦联合卡托普利治疗原发性高血压的临床疗效。方法选择2010年1月～2011年1月于我院住院治疗的原发性高血压患者58例,随机分为联合组和对照组各29例,对照组29例予缬沙坦,联合组同时给予卡托普利片,比较两组的疗效及不良反应。结果与对照组比较,联合组的总有效率明显增高,差异有统计学意义。治疗前后所有患者肝肾功能、血尿常规等生化指标未见明显变化,结论缬沙坦联合卡托普利治疗原发性高血压疗效明显优于单纯应用缬沙坦治疗的疗效,安全性好,值得广泛推广和应用。

Objective To observe the clinical efficacy of Valsartan combined with Captopril treatment of essential hyper tension. Methods All of 58 patients with essential hypertension according to random number table were randomly divided into the combination group and control group 29 cases from January 2010 to January 2011 in our hospital, the control group of 29 patients was given Valerian losartan, combination group was given captopril, and two groups were compared of the efficacy and adverse reactions. Results Compared with the control group, the total effective rate in the combination group was significantly higher, the difference was significant（P 〈 0.05）. Liver and kidney function and urine routine in all patients before and after treatment had no significant changes in biochemical parameters. Conclusion The efficacy of Valsartan combined with Captopril treatment of primary hypertension is significantly better than the simple application of Valsartan treatment, and it is safety, good, significantly improve the efficacy, and it is worth widely promoted and applied.