期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

非小细胞肺癌患者术前血清中MMP-3和MMP-7检测的意义 被引量：1

Serum expressions and significance of MMP-3 and MMP-7 in non-small cell lung carcinoma before operation
下载PDF
导出
摘要 目的应用ELISA法分别检测120例非小细胞肺癌患者和120例正常成人血清中基质金属蛋白酶-3(MMP-3)和基质金属蛋白酶-7(MMP-7)的表达,并分析二者的表达与非小细胞肺癌患者的分化程度、淋巴结转移及临床分期的关系,为术前判断肿瘤的生物学行为提供理论帮助。方法选取我院确诊的120例非小细胞肺癌需进行手术治疗的术前患者作为观察组,选取120例体检证实为健康的成人血清作为对照组,应用酶联免疫吸附实验检测两组血清中MMP-3和MMP-7的含量,分析其意义及相关性。结果观察组患者血清中MMP-3和MMP-7的表达明显高于对照组,术前血清中MMP-3和MMP-7的表达与肿瘤的分化程度、淋巴结转移及临床分期密切相关。结果显示非小细胞肺癌中MMP-3和MMP-7的表达具有正相关性。结论非小细胞肺癌患者血清中MMP-3和MMP-7的表达升高,MMP-3和MMP-7在肿瘤的进展中具有促进作用,术前联合检测血清中MMP-3和MMP-7的表达可能有助于判断预后。 Objective To investigate the expressions of MMP-3 and MMP-7 in 120 cases with non-small cell lung carcinoma and 120 cases normal adults for observing their clinical significance in neoplasm. Methods We detected the serum expressions of MMP-3 and MMP-7 by ELISA in the non-small cell lung carcinoma before opeartion and normal adults. Their expressions and clinical significance were analyzed in the non-small cell lung carcinoma. Results The serum expres- sions of MMP-3 and MMP-7 were higher in the neoplasm than in normal adults. Their expressions were correlated with differentiation, clinical stage and lymph node metastasis. Positive correlation between MMP-3 and MMP-7 was found in neoplasm before operation. Conclusion The higher serum expressions of MMP-3 and MMP-7 were found in non-small cell lung carcinoma before operation. The synergistic effect of MMP-3 and MMP-7 may promote the development of neo- plasm. The expressions of MMP-3 and MMP-7 may be helpful to judge the prognosis in non-small cell lung carcinoma.
作者 胡天军
机构地区 宁波市第二医院胸外科
出处 《中国现代医生》 2012年第6期114-115,共2页 China Modern Doctor
关键词 非小细胞肺癌 基质金属蛋白酶-3 基质金属蛋白酶-7 酶联免疫吸附实验 Non-small cell lung carcinoma MMP-3 MMP-7 ELISA
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献8

  • 1Kren L,Goncharuk VN,Krenová Z,et al.Expression of matrix metalloproteinases 3,10 and 11 (stromelysins 1,2 and 3) and matrix metalloproteinase 7 (matrilysin) by cancer cells in non-small cell lung neoplasms.Clinicopathologic studies[J].Cesk Patol,2006,42(1):16-19.
  • 2Safranek J,Pesta M,Holubec L,et al.Expression of MMP-7,MMP-9,TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease[J].Anticancer Res,2009,29(7):2513-2517.
  • 3Salgia R.Prognostic significance of angiogenesis and angiogenic growth factors in norsmall cell lung cancer[J].Cancer,2011,117(17):3889-3899.
  • 4宋宝辉,杨清波,张金涛,于建渤.MMP-7和uPAR在非小细胞肺癌的表达及其意义[J].临床肿瘤学杂志,2009,14(12):1069-1072. 被引量：3
  • 5Liu H,Zhang T,Li X,et al.Predictive value of MMP-7 expression for response to chemotherapy and survival in patients with non-small cell lung cancer[J].Cancer Sci,2008,99(11):2185-2192.
  • 6Liu D,Nakano J,Ishikawa S,et al.Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation,and a poor prognosis in non-small cell lung cance[J].Lung Cancer,2007,58(3):384-391.
  • 7肖敏,黄孙卉.MMP-3和p53蛋白在乳腺癌组织中的表达及其与肿瘤转移的关系[J].实用肿瘤学杂志,2008,22(6):514-516. 被引量：3
  • 8Safranek J,Holubec L Jr,Topolcan O,et al.Expression of mRNA MMP-7 and mRNA TIMP-1 in non-small cell lung cancer[J].Anticancer Res,2007,27 (4C):2953-2956.

二级参考文献16

  • 1O - Chamenrat P, Rhys - Evans PH, Eccles SA. Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck [ J ]. Arch Otolaryngol Head Neck Surg, 2001,127(7) :813 -820.
  • 2Kerkela E, Ala - aho R, Jeskanen L, et al. Differential patterns of stromelysin - 2 ( MMP - 10) and MT1 - MMP( MMP - 14) expression in epithelial skin cancers [ J ]. Br J Cancer,2001,84(5) :659 -669.
  • 3Kerkela E, Ala - aho R, Jeskanen L, et al. Expression of hu- man macrophage metaUoelastase( MMP- 12)by tumor cells in skin cancer[J]. J Invest Dermatol,2000,114(6) :1113 -1119.
  • 4Ignar DM, Andrews JL, Witherspoon SM, et al. Inhibition of establishment of primary and micrometastatic tumors by a urokinase plasminogen activator receptor antagonist [ J ]. Clin Exp Metastasis, 1998, 16(1) : 9 -20.
  • 5Vihinen P, Kahari VM. Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets [ J ]. Int J Cancer, 2002, 99(2) : 157 - 166.
  • 6Chetty C, Bhoopathi P, Joseph P, et al. Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice[ J]. Mol Cancer Ther, 2006, 5(9):2289-2299.
  • 7Iniesta P, Moran A, De Juan C, et al. Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non- small cell lung cancer [ J]. Oncol Rep, 2007, 17 ( 1 ) : 217 - 223.
  • 8Rao JS, Gondi C, Chetty C, et al. Inhibition of invasion, angio- genesis, tumor growth, and metastasis by adenovirus-mediated transfer of antisense uPAR and MMP-9 in non-small cell lung cancer cells[J]. Mol Cancer Ther, 2005, 4(9) : 1399 - 1408.
  • 9Almasi CE, Hyer-Hansen G, Christensen IJ, et al. prognostic impact of liberated domain I of the urokinase plasminogen activator receptor in squamous cell lung cancer tissue[J]. Lung Cancer, 2005, 48(3) : 349 -355.
  • 10Sauter W, Rosenberger A, Beckmann L, et al. Matrix metalloproteinase 1 ( MMP1 ) is associated with early-onset lung cancer [ J ]. Cancer Epidemiol Biomarkers Prey, 2008, 17 (5) : 1127 - 1135.

共引文献4

同被引文献25

  • 1于学燕,王永刚.MMP-2和MMP-3在非小细胞肺癌组织中的表达及意义[J].现代肿瘤医学,2005,13(4):461-463. 被引量：5
  • 2于秀文,程慧,王静芬.大肠癌组织中MMP-3的表达及其临床意义[J].中华肿瘤防治杂志,2006,13(1):45-47. 被引量：11
  • 3韦尉东,温浙盛,苏晓东,林鹏,戎铁华,陈丽昆.899例非小细胞肺癌完全切除术后的多因素生存分析[J].癌症,2007,26(11):1231-1236. 被引量：13
  • 4SUN Q,ZHAO C,XIA L,et al.High expression of matrix metalloproteinase-9 indicates poor prognosis in human hilar cholangiocarcinoma[J].Int J Clin Exp Pathol,2014,7(9):6157-6164.
  • 5AMALINEI C,CARUNTU I D,GIUSCA S E,et al.Matrix metalloproteinases involvement in pathologic conditions[J].Rom J Morphol Embryol,2010,51(2):215-228.
  • 6FANG S,JIN X,WANG R,et al.Polymorphisms in the MMP-1and MMP-3 promoter and non-small cell lung carcinoma in North China[J].Carcinogenesis,2005,26(2):481-486.
  • 7JAZIEH A R,HUSSAIN M,HOWINGTON J A,et al.Prognostic factors in patients with surgically resected stagesⅠandⅡnonsmall cell lung cancer[J].Ann Thorac Surg,2000,70(4):1168-1171.
  • 8TAKEDA S,FUKAI S,KOMATSU H,et al.Impact of large tumor size on survival after rescection of pathologically node negative(p NO)non-small cell lung cancer[J].Ann Thorac Surg,2005,79(4):1142-1146.
  • 9MOLINA J R,YANG P,CASSIVI S D,et al.Non-small cell lung cancer:epidemiology,risk factors,treatment,and survivorship[J].Mayo Chin Proc,2008,83(5):584-594.
  • 10EL-BADRAWY M K,YOUSEF A M,SHAALAN D,et al.Matrix metalloproteinase-9 expression in lung cancer patients and its relation to serum MMP-9 activity,pathologic type,and prognosis[J].J Bronchology Interv Pulmonol,2014,21(4):327-334.

引证文献1

二级引证文献5

中国现代医生
2012年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部