摘要
目的探讨老年心力衰竭(HF)患者血浆N-末端脑钠肽(NT-proBNP)与心力衰竭严重程度的关系,评价其对老年心力衰竭患者的临床意义。方法老年心力衰竭患者72例,根据纽约心脏病协会(NYHA)心功能分级,其中NYHAⅡ级26例、Ⅲ级28例、Ⅳ级18例,同时选取34例心功能正常老年人作为对照组,分别测定血浆NT-proBNP值及左室射血分数(LVEF)。结果老年心力衰竭组NT-proBNP数值明显高于对照组,且其数值随心功能分级的升高而增高,与LVEF呈负相关(P<0.05)。结论老年心力衰竭患者血NT-proBNP水平与心力衰竭严重程度存在相关性,可客观反映老年心力衰竭患者的心功能状态。
Objective To investigate the relationship between N-terminal pro-brain natriuretic peptide （NT-proBNP） levels in elderly patients with the deterioration of the heart failure severity. Methods All of 72 elderly patiants with heat failure were selected,among them 26 cases subjects with NYHA Ⅱ ,28 subjects with NYHA Ⅲ ,18 subjects with NYHA Ⅳ ）, and 34 elderly subjects were enrolled in cintorl group. The plasma level of NT-proBNP were detected by electrochemiluminescence immunoassay methed,and the structure and fuction of left ventricle were examined by echocardiography. Results The plasma level of NT-proBNP increased significantly in elderly patients with heart failure compard with control groups, and the dregreed of NYHA.The levels of plasma NT-proBNP were negatively correlated with LVEF. Conclusion The plasma level of NT-proBNP has the realationship with the deterioration of the heart failure severity, and it can be used to evaluate the function in the elderly patients with heart failure.
出处
《中国现代医生》
2012年第6期141-142,共2页
China Modern Doctor
关键词
老年
N-末端脑钠肽
心力衰竭
左室射血分数
Elderly patients
N-terminal pro-brain natriuretic peptide （NT-proBNP）
Heart failure （HF）
LVEF
