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mTOR信号通路和肿瘤治疗 被引量：5

mTOR signaling pathway:a target for cancer therapy
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摘要 PI3K蛋白激酶类家族的mTOR作为信号传导分子,在细胞的生长、增殖、分化和凋亡等许多生理过程中起着重要的控制作用,笔者就其信号通路的构成以及其上、下游信号的特点作一概述,并初步阐明mTOR信号通路与肿瘤治疗的关系。 As a signaling transducer, mTOR, one member of the PI3K family, plays an important role in regulation of a variety of physiological functions involving cell growth, proliferation, differentiation and apoptosis etc. This paper overviews the composition of mTOR signaling complexes and the specific functions of the molecules up- and down-stream, and briefly elucidates the role ofmTOR signaling pathway in cancer therapy.
作者 赵凡 李灼日
机构地区 南华大学医学院 海南省人民医院肝胆外科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2012年第2期204-208,共5页 China Journal of General Surgery
关键词 肿瘤/治疗 哺乳动物雷帕霉素靶蛋白 信号传导 综述文献 Neoplasms/ther Mammalian Target of Rapamycin Signal Transduction Review
分类号 R730.2 [医药卫生—肿瘤]
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参考文献2

二级参考文献143

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共引文献62

同被引文献71

  • 1刘民锋,罗剑,余险峰,唐启彬,陈勇军,邹声泉.PTEN和mTOR信号转导通路在胆管癌发展中作用的研究[J].中国普通外科杂志,2006,15(4):274-276. 被引量：13
  • 2董崇海,曲玲,赵清喜,李杰,郭春霞,刁春艳,王德仙.散发性结直肠癌、腺瘤组织中hMLH1和突变型p53表达[J].中国肿瘤,2007,16(2):123-126. 被引量：7
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  • 10Cridelli C, Malone P, Rossi A. The potential role of mTOR inhibitorsin non-small cell lung cancer[J]. Oncologist, 2008, 13(2):139-147.

引证文献5

二级引证文献8

中国普通外科杂志
2012年 第2期

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