急性脑梗死患者血小板微颗粒水平的研究

Study of PMP levels in patients with acute cerebral infarctions

目的研究急性脑梗死患者的血小板微颗粒(PMP)水平及其临床意义。方法检测并比较80例急性脑梗死患者及80例健康人PMP水平,比较不同面积、不同TOAST分型脑梗死患者PMP水平的差异,检测脑梗死治疗后不同时期PMP的动态变化。结果与健康对照组比较急性脑梗死患者PMP水平较高,且大面积脑梗死患者PMP水平较其他脑梗死患者更高。不同TOAST分型脑梗死患者PMP水平差异显著。治疗后脑梗死患者PMP水平呈动态下降。结论急性脑梗死患者存在血小板活化,检测血液PMP水平将有助于急性脑梗死的诊断和治疗。

Objective ：To study serum levels and their clinical significance of platelet microparticle in patients with acute cerebral infarctions.Methods The serum levels of PMP were detected and compared between acute cerebral infarction group consisting of 80 patients and control group consisting of 80 health persons.Also the PMP levels of patients with different infarction areas and of different TOAST subtypes were compared and the PMP levers before treatment,after three-days＇,one-weeks＇ and two-weeks＇ treatment were detected,too.Results Compared with the control,the serum levels of PMP were higher in patients with acute cerebral infarctions,and the larger the infarction areas were,the higher the PMP levels were.There was significant difference among patients of different TOAST subtypes.After treatment,the PMP levers of the patients decreased dynamically.Conclusion Platelet is activated in patients with acute cerebral infarctions.Testing the serum levels of PMP helps to diagnose and treat cerebral infarctions.