中枢性低钠血症与非创伤性脑出血的相关研究

Research of central hypornatremia and spontaneous cerebral hemorrhage

目的研究中枢性低钠血症与非创伤性脑出血患者的预后及出血部位的关系。方法分析397例脑出血患者,分为低钠血症及正常血钠两组,研究其死亡率差异以及低钠血症与出血部位的关系。结论 397例患者中58例患者发生低钠血症,1例诊断抗利尿激素分泌异常综合征(SIADH),57例为脑耗盐综合征(CSWS),死亡10例,采用χ2检验,低钠血症死亡率高于正常血钠组(P=0.014,P<0.05),低钠血症与死亡率呈正相关(Pearson相关系数r=0.123);两组脑出血部位分布不同,低钠血症患者中蛛网膜下腔出血多于基底节区出血,频数差异有显著性(P=0.01,P<0.0125)。结果中枢性低钠血症发生与脑出血部位相关,中枢性低钠血症中CSWS较SIADH更易发生。低钠组患者死亡率明显增高,血钠水平可预测疾病危险程度。

Objective Studying the relationship of motality and bleeding part in cerebral hemorrhage patients obtained hyponatremia.Methods Reviewed 397 patients of spontaneous cerebral hemorrhage in two years,58 cases obtained hyponatremia among them.Analysed the motality and parts distribution in two gropes.Results 58 cases obtained hyponatremia among 397cases,one of them diagnosed SIADH,the other 57 cases were CSWS.Using χ2-test,mortility of patinat obtiained hyponatremia is higher than those in normal blood sodiumin（P=0.014,P0.05;Pearson＇s R=0.123）.Parts distribution of hyponatremia was different in two groups（P=0.01,P0.0125）.Conclusions CSWS is more common than SIADH in hyponatremia.Morbility of hyponatremia is related to bleeding parts.