肿瘤坏死因子相关性凋亡诱导配体、骨保护素与脑卒中被引量：6

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摘要目前发现细胞凋亡的死亡受体配体通路包括：fas-fasL、TNF-α-TNFR、TRAIL-DR4/DR5及APO-3L-DR3等。肿瘤坏死因子相关性凋亡诱导配体（tumour necrosis factor related apoptosis inducing ligand,TRAIL）因为早年发现其对正常细胞的无毒性而引起了人们的广泛关注,而其可溶性受体骨保护素（osteoprotegerin,OPG）可能是与动脉粥样硬化有关的一种保护性因子。脑卒中的发病过程有神经元凋亡参与,而与其病理基础相关的动脉粥样硬化可能与OPG关系密切,本文就TRAIL、OPG与脑卒中有关的研究进展加以综述。

作者柏希山王满侠刘利宁

机构地区兰州市安宁区人民医院内科兰州大学第二医院神经内科

出处《脑与神经疾病杂志》 2012年第1期79-80,F0003,共3页 Journal of Brain and Nervous Diseases

关键词肿瘤坏死因子凋亡诱导配体骨保护素脑卒中相关性 APOPTOSIS 动脉粥样硬化 LIGAND

分类号 R741.02 [医药卫生—神经病学与精神病学]

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参考文献27

1Wiley SR,Schooley K,Smolak PJ,et al.Identification and characterization of a new member of the TNF family that induces apoptosis.Immunity,1995,3:673-682.
2Pitti RM,Marsters SA,Ruppert S,et al.Induction of apoptosis by Apo-2 ligand,a new member of the tumor necrosis factor cytokine family.J Biol Chem,1996,271:12687-12690.
3Spierings DC,de Vries EG,Vellenga E,et al.Tissue distribution of the death ligand TRAIL and its receptors.J Histochem Cytochem,2004,52:821-831.
4Aggarwal BB,Bhardwaj U,Takada Y.Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors.Vitam Horm,2004,67:453-483.
5Simonet WS,Lacey DL,Dunstan CR,et al.Osteoprotegerin:a novel secreted protein involved in the regulation of bone density.Cell,1997,89:309-319.
6Tsuda E,Goto M,Mochizuki S,et al.Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.Biochem Biophys Res Commun,1997,234:137-142.
7Tomoyasu A,Goto M,Fujise N,et al.Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor.Biochem Biophys Res Commun,1998,245:382-387.
8Van Campenhout A,Golledge J.Osteoprotegerin,vascular calcification and atherosclerosis.Atherosclerosis,2009,204:321-329.
9Martin-Villalba A,Herr I,Jeremias I,et al.CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons.J Neurosci,1999,19:3809-3817.
10Herr I,Martin-Villalba A,Kurz E,et al.FK506 prevents stroke-induced generation of ceramide and apoptosis signaling.Brain Res,1999,826:210-219.

二级参考文献9

1脑卒中患者临床神经功能缺损程度评分标准（1995）[J].中华神经科杂志,1996,29(6):381-383. 被引量：15727
2Liu-Deryke X, Rhoney DH. Cerebral vasospasm after aneurysmal subarachnoid hemorrhage: an review of pharmacologic management [ J]. Expert Opin Pharmacotherapy, 2006, 26 (2) : 182 - 203.
3Ogihara K, Zubkov AY, Bernanke DH, et al. Oxyhemoglobin-induced apoptosis in cultured endothelial cells[ J ]. J Neurosurg, 1999, 91 (3) : 459 - 465.
4Zhou C, Yamaguchi M, Kusaka G, et al. Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage [ J]. J Cereb Blood Flow Metab, 2004, 24(4) : 419 -431.
5Humphreys RC, Halpern W. Trail receptors: targets for cancer therapy [J]. Adv Exp Med Biol, 2008, 615:127-158.
6Kruyt FA. TRAIL and cancer therapy [ J ]. Cancer Lett, 2008, 263 (1): 14-25.
7Mazumder S, Plesca D, Almasan A. Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis [ J ]. Methods Mol Biol, 2008, 414:13 -21.
8Corallini F, Rimondi E, Secchiero P. TRAIL and osteoprotegerin: a role in endothelial physiopathology ? [ J]. Front Biosci, 2008, 13 : 135 - 147.
9Goehuico BR, Zhang J, Ma BY, et al. TRAIL expression in vascular smooth muscle [ J]. Am J Physiol Lung Cell Mol Physiol, 2000, 278 (5) : L1045 - 1050.