老年高血压患者血压变异性与早期肾功能损害的相关性研究

The relevant research between blood pressure variability and early renal dysfunction in old patients with essential hypertension

目的观察老年高血压患者血压变异性对早期肾功能损害的影响。方法对62例老年原发性高血压患者按照24 h动态血压变异性高低将其分为A组和B组(A组血压变异性小于B组)。进行24 h动态血压监测和血清胱抑素C及肾功能生化测定,观察比较患者血压变异性对早期肾功能损害的影响。结果两组患者血压变异性有显著差异(P<0.05);两组血肌酐、尿素氮结果无显著性差异(P>0.05);A组血清胱抑素C含量明显低于B组,有显著性差异(P<0.01)。结论老年高血压患者血压变异性与高血压性早期肾脏损害密切相关。

Objective To observe the relevance between blood pressure variability and early renal dysfunction in old patients with essential hypertension.Methods Sixty-one old patients were divided into group A and group B based on the variability of 24 h systolic blood pressure（The blood pressure variability of group A was lower than group B）.24 h systolic blood pressure,serum Cys-C and renal function determination were recorded.Results There were significant differences in blood pressure variability（P0.05） and Cys-C level（P0.01） between two groups;however,no differences were found in the levels of serum creatinine and BUN between two groups（P0.05）.Conclusion Blood pressure variability is closely related to early hypertensive renal injury in old patients with essential hypertension.