光动力治疗基底细胞癌的疗效观察

Curative effect of photodynamic therapy on basal cell carcinoma

目的观察光动力疗法治疗基底细胞癌的临床治疗效果。方法将61例基底细胞癌患者用光敏剂5-氨基酮戊酸(ALA)涂于皮损处,3 h后红光照射,能量密度为100～120 J/cm2,时间约20 min,每周照射1次,共4周,疗程结束后评价疗效。结果 61例基底细胞癌患者中,完全缓解45例,部分缓解9例,无效7例,总有效率88.52%(54/61)。所有患者无严重毒副作用。结论光动力疗法治疗基底细胞癌痛苦小、无创伤、无副作用,是一种安全有效的治疗方法。

Objective To study the clinical curative effect of photodynamic therapy on basal cell carcinoma.Methods Sixty one cases of basal cell carcinoma were given with photosensitizer 5-amino acid（ALA） ketone spreading on skin lesions,reddish illumination was taken at 3 h later with energy density at 100 ~ 120 J/cm2,20 min/time,weekly for a total of 4 weeks,and the result of treatment had been evaluated.Results Among sixty one patients with basal cell carcinoma,45 patients were completely remitted after treatment,partially remitted in 9 cases and invalid in 7 cases,hence the total effective rate was 88.52%（54/61）.There was no serious adverse reaction occurred during whole treatment course.Conclusion The application of photodynamic therapy in treatment of basal cell carcinoma is effective with less painfulness,non-invasiveness,without side effect,hence it is a safe and effective method for treatment of basal cell carcinoma.