氟比洛芬脂超前镇痛预防全麻拔管期心血管反应的临床观察

Clinical observation of the effects of preemptive analgesia of flurbiprofen on cardiovascular responses to tracheal extubation

目的观察氟比洛芬脂对腹腔镜下胆囊切除病人气管拔管时心血管反应的预防作用。方法选择择期腹腔镜下胆囊切除患者42例随机分为实验组和对照组,各21例,实验组于手术开始前给予氟比洛芬脂50 mg静脉推注,余下麻醉处理同对照组。在围拔管期观察患者血压、呼吸、心率、拔管时间、清醒时间及有无恶心、呕吐等不良反应。结果实验组拔管时血压、呼吸、心率平稳,明显优于(P<0.05),两组间拔管时间、清醒时间无显著差异(P>0.05)。结论氟比洛芬脂超前镇痛能有效预防腹腔镜下胆囊切除病人气管拔管时的心血管反应且副作用少。

Objective To observe the effects of preemptive analgesia of flurbiprofen on cardiovascular responses to tracheal extubation.Methods Forty-two ASA Ⅰ or Ⅱ patients undergoing elective laparoscopic cholecystectomy were randomly divided into two groups： Test group and Control group,21 cases each.Patients in Test group received intravenous administration of flurbiprofen before operation while those in the Control group did not.SP,DP and HR of all patients were recorded during extubation and at 1,5 and 10 min after extubation.Results BP and HR were higher in Test group than those in Control group at 1,5 and 10 min after extubation（P〈0.05 or P〈0.01）.Conclusion Preemptive analgesia of flurbiprofen can decrease adverse cardiovascular response to extubation in patients undergoing elective laparoscopic cholecystectomy.