氢键诱导的不对称催化反应研究进展

Recent progress in asymmetric catalysis induced by hydrogen bonding

氢键催化在不对称有机催化领域已经有了重大进展。手性有机小分子通过氢键活化羰基化合物和亚胺等得到极大的关注。主要对手性硫脲和二醇催化剂的氢键催化进行综述。重点介绍不同手性硫脲和二醇催化剂的催化活性及其在各类不对称催化反应中(包括不对称Strecker反应、Pictet-Spengler反应、Mannich反应、Baylis-Hillman反应、Diels-Alder反应以及Michael反应)的催化效果。

Hydrogen bonding catalysis has been developed recently in area of asymmetric organocatalysis.Hydrogen bonding activation of carbonyl compounds and imines have attracted much attention as chiral organocatalyst.This review focuses on the chiral thioureas and diols as organocatalyst in hydrogen bonding catalysis.Focus on introducing the catalytic activity of different kinds of chiral thioureas and diols,and their catalytic effect in different varieties of asymmetric catalytic reaction.