L-酒石酸正丁酯萃取拆分酮洛芬外消旋体

Separation of ketoprofen enantiomers by extraction with L-n-butyl tartaric ester

研究了酮洛芬对映体在含疏水性手性选择体L-酒石酸正丁酯的1,2-二氯乙烷和甲醇水两相体系中的萃取分配行为。考察了酒石酸酯的种类、L-酒石酸正丁酯的浓度、有机溶剂的种类及甲醇溶液的浓度对分配系数K和分离因子α的影响。L-酒石酸正丁酯与S-酮洛芬对映体比L-酒石酸正丁酯与R-酮洛芬对映体形成更稳定的非对映体复合物;以0.2mol/L L-酒石酸正丁酯为手性选择体,以1,2-二氯乙烷为有机溶剂,甲醇浓度为10%时,萃取分离效果最好。

Distribution behavior of ketoprofen enantiomers was examined in the methanol aqueous and organic solvent mixture containing L-n-butyl tartaric ester.The kinds of tartaric esters,the concentration of L-n-butyl tartaric ester and the methanol aqueous,the kinds of organic solvent on the distribution behavior were investigated.The results show that L-n-butyl tartaric ester form more stable diastereomeric complexes with S-enantiomer than that with R-enantiomer.The best enantioselectivity for ketoprofen enantiomers was in the separation system consisted of 0.20 mol/L L-n-butyl tartaric ester as chiral selector,1,2-dichloroethane as organic solvent and 10% methanol aqueous as solvent for ketoprofen.