多西紫杉醇与卡培他滨联合化疗治疗复发转移性乳腺癌疗效观察

Efficacy observation of docetaxel combined with capecitabine in treatment of breast cancer

目的:探讨多西紫杉醇与卡培他滨联合化疗治疗复发转移性乳腺癌的疗效,为临床治疗提供参考。方法:对本院2009年2月～2011年1月收治的25例乳腺癌患者均采用多西紫杉醇与卡培他滨联合化疗的治疗方案,观察患者的疗效。结果:25例患者中CR2例(8.0%),PR6例(24.0%),SD10例(40.0%),PD7例(28.0%),总有效率为32.0%。19例患者出现骨髓抑制现象,17例出现恶心、呕吐,9例患者出现口腔黏膜炎,13例患者脱发。结论:多西紫杉醇联合卡培他滨治疗复发转移性乳腺癌患者有较好疗效,不良反应较轻,经治疗很快恢复,值得在临床上进一步观察应用。

Objective： To investigate the efficacy of docetaxel combined with capecitabine in the treatment of breast cancer, and provide a reference for clinical treatment. Methods： Twenty five cases of breast cancer patients in our hospital from February 2009 to January 2011 were treated with docetaxel combined with capecitabine, the efficacy were observed. Results： In 25 cases of patients, there were 2 cases （8.0%） of CR, 6 cases （24.0%） of PR, 10 cases （40.0%） of SD, 7 cases （28.0%） of PD, the total effective rate was 32.0%. The bone marrow suppression were in 19 cases, nausea, vomiting were in 17 cases, oral mucositis were in 9 cases, hair loss were in 13 cases. Conclusion： Efficacy of docetaxel combined with capecitabine in treatment of breast cancer is better, patients recovery quickly after treatment and its side effects is less, it is worthy for further clinical application.