活化硼氢化钠在有机合成中的应用

The Applications of the Activated Sodium Borohydride in Organic Synthesis

介绍了有机合成反应中NaBH4与添加剂共同作用的反应,其中包括烯烃和炔烃的还原,羧酸的还原,氨基酸及其衍生物的还原,羧酸酯的还原,酰胺的还原,腈基的还原,酰氯的还原,硝基化合物的还原,醛酮的还原等。与LiAlH4的还原相比较,其反应条件更温和,反应过程更安全、易操控、易放大。

Introduced the applications of the activated sodium borohydride . It concluded reduction of alkene, alkyne, carboxylic acid, carboxylic acid ester, amide, nitrile group, acyl chloride, nitro group, aldehydes, ketones, amino acids as well as their derivatives. Comparing to the reduction of lithium aluminum hydride, it had milder reaction conditions, more secure reaction process and it was more easily controlled and amplified.