啮齿类动物睾丸Leydig干细胞系研究进展

Progress on the research of stem Leydig cell line in the testis of rodents

Leydig细胞是生成睾酮的主要场所,其分化是男性个体发育的一个标志性事件。近年来,出现许多关于Leydig干细胞的研究,以期明确Leydig干细胞分化为成熟型Leydig细胞这一过程中所涉及的分子改变及其发生机制。本文就大鼠、小鼠的胎儿型及成熟型Leydig细胞个体发育及相关激素的调控机制进行了综述。

Objective Leydig cells are the primary source of generating testosterone,and the differentiation of Leydig cells in testes is a signature event of the ontogenesis of males.Many studies elucidating the molecular changes and the mechanisms involved in the progressive differentiation of stem Leydig cells into adult Leydig cells have been appeared recently.Herein,the hormonal regulation on the ontogenesis of fetal and mature Leydig cells was reviewed in this paper.