降脂颗粒药效学研究

Pharmocodynamics Study of Jiangzhi Granule

目的:研究降脂颗粒对实验性高脂血症的影响。方法:建立大鼠实验性高脂血症模型,分为正常对照组、模型组、血脂康组(0.125 g.kg-1)、降脂颗粒高、中、低剂量组(8.0,4.0,2.0 g.kg-1),ig给药4周;建立小鼠实验性高脂血症模型,分为正常对照组、模型组、血脂康组(0.18 g.kg-1)、降脂颗粒高、中、低剂量组(10.0,5.0,2.5 g.kg-1),ig给药7 d;建立鹌鹑鼠实验性高脂血症模型,分为正常对照组、模型组、血脂康组(0.14 g.kg-1)、降脂颗粒高、中、低剂量组(8.0,4.0,2.0 g.kg-1),ig给药12周。分别测定3种动物模型各组血清甘油三酯(TG)、胆固醇(CHO)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的含量,并进行鹌鹑动脉粥样硬化斑块的病理组织学检查。结果:降脂颗粒3个剂量组均可明显降低实验性高脂血症大鼠、小鼠及鹌鹑血清中CHO,TG,LDL-C的含量,逆转动脉硬化指数(HDL-C/CHO)的降低,对HDL-C和极低密度脂蛋白胆固醇(VLDL-C)水平无明显影响。结论:降脂颗粒有明显的降血脂作用和预防动脉粥样硬化斑块形成的作用。

Objective：To study the effect of Jiangzhi granule（JZG） on hyperlipemia models.Method：Hyperlipemia models were established in mice,rat and quails.All animals were randomly divided into normal group,model group,xuezhikang group,JZG high,middle and low dose group.The dosage for mice,rat and quails was 10.0,5.0,2.5 g·kg-1,8.0,4.0,2.0 g·kg-1 and 8.0,4.0,2.0 g·kg-1,respectively Administration course was one week for mouse,four weeks for rats and 12 weeks for quails.The content of cholestero（CHO）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterd（LDL-C） in serum was determined after administration The atherosclerotic plaque in quail hyperlipemia models was exmined by histopathologic examination.Result：The content of CHO,TG,LDL-C in serum of mice,rats and quails was decreased remarkedly.The decrease of HDL-C/CHO index was reversed.Atheroselerotic plaque in quail lightened obviously.No change of HDL-C and VLDL-C were not found.Conclusion：JZG can effectively decrease the serum lipid and prevent the formation of atherosclerosis.