川芎嗪对血小板活化钙信号的影响及作用机制

Tetramethylpyrazine Effects Calcium Signaling under Platelet Activation

分析国内外在研究川芎嗪与血小板活化时游离钙离子浓度关系方面的文献报道,为进一步研究川芎嗪的药理作用提供参考。通过检索中国知网、万方及PubMed等数据库,查阅整理上述研究领域的相关文献25篇。目前研究显示,血小板活化时血小板胞质内钙离子浓度升高,其升高取决于细胞外血小板膜外基质中的钙内流和血小板细胞内钙池的钙释放。川芎嗪主要通过抑制血小板内钙离子浓度升高,发挥抑制血小板活化的药理作用。川芎嗪抑制血小板活化的具体作用途径机制仍不明了,目前的研究大多支持川芎嗪通过抑制胞内游离钙离子浓度升高进而抑制血小板活化这一结论,但这些研究多为描述性的,缺少动态观察川芎嗪对钙离子作用的相关研究。

To analyze the reports on the relationships between tetramethylpyrazine（TMPZ） and the intracellular free calcium concentration under platelet activation,and to provide hint for further study of the pharmacological actions of TMPZ.By retrieving the following databases such CNKI,Wanfang,PubMed,and so on,to read relative publications.The current studies show that the intracellular calcium concentration in platelets increases due to platelet activation,which depends on the entry of calcium in the extracellular matrix and the release of calcium in endoplasmic reticulum.TMPZ plays its inhibitory role on platelet activation mainly through the suppression on the increase of the intracellular calcium concentration.It still remains unknown about the mechanism underlying the inhibition on platelet activation by TMPZ,and most of the studies suggest that TMPZ inhibits the intracellular free calcium concentration,leading to the suppression of platelet activation.However,those studies are much descriptive,instead of time-lapse observation on it.