经皮椎体成形术联合鲑鱼降钙素治疗骨质疏松椎体压缩性骨折的临床观察

The clinical observation of percutaneous vertebroplasty combined with salmon calcitonin for the treatment of osteoporotic vertebral compression fracture

目的通过对比研究,观察经皮椎体成形术联合密盖息治疗骨质疏松性椎体压缩骨折的疗效。方法 2008年2月至2011年1月,我们将脊柱压缩性骨折行PVP手术患者随机分成两组,治疗组在术后当日予以肌注鲑鱼降钙素,治疗3周后改用鼻喷剂,连续使用至少3个月;观察组单纯予以椎体成形术,分别在术前,术后1周,1月,3月以及6月采用VAS评分以及Barthel指数来评估两组治疗效果。结果两组患者均在术后疼痛均有明显的缓解,但是相对于观察组,治疗组在术后1月,3月,以及6月疼痛缓解以及生活质量提高更为明显,随着随访时间的延长,这种差别越来越明显。结论椎体成形术结合鲑鱼降钙素治疗骨质疏松性椎体压缩性骨折更能缓解患者的疼痛,提高患者的生活质量,值得临床推广。

Objective To observe percutaneous vertebroplasty（PVP） combined with salmon calcitonin for the treatment of patients with osteoporotic vertebral compression fracture（OVCF） through comparative research.Methods The OVCF patients treated with PVP from Feb 2008 to Jan 2011 were randomly divided into two groups.The patients in treatment group were treated with intramuscular injection of salmon calcitonin after the operation for 3 weeks and nasal spray of salmon calcitonin after that at least for 3 months.The patients in control group were treated with PVP only.The clinical efficacies of the two groups were assessed with the visual analogue pain score（VAS） and the capability of living score（Barthel Index） before the operation,and 1 week,1 month,3 months,and 6 months after the operation,respectively.Results Pain of patients in both two groups was relieved significantly.However,the pain relieve at 1-,3-,and 6-month after the operation and the improvement of life quality in the treatment group were more significant than those in the control group.This difference became more significant along with the follow up time.Conclusion PVP combined with salmon calcitonin can effectively relieve the pain of OVCF patients and improve their life quality.It is worthy of clinical promotion.