鄱阳湖微生物资源多样性及药用开发研究进展及策略

Lake Poyang Microbial Diversity and Medicinal Research and Development Progress and Strategy

研究发现,湖泊环境的微生物中蕴藏着丰富的生物和化学多样性,是创新药物先导化合物的重要源泉。鄱阳湖特殊的地理及气候特征,形成了一个独特的自然环境,生存于其中的微生物必然具备相对独特的分子生物学机制和生理生化特性,它们很可能具有一些不相同的代谢途径和次级代谢产物。因此有必要构建鄱阳湖环境微生物宏基因组文库,探讨微生物的多样性,并从鄱阳湖环境微生物中寻找高新活性先导化合物。

Study found that lake environmental microorganisms were rich in biological and chemical diversity,innovation was the important source of lead compounds in drug discovery.The Lake Poyang special geographical and climatic characteristics,the formation of a unique natural environment,survival in which microorganisms must have a relatively unique molecular mechanisms and physiological and biochemical characteristics,they are likely to have some different metabolic pathways and secondary metabolites.It is necessary to construct the Lake Poyang environmental microbial metagenomic library,to investigate the microbial diversity,and from the Lake Poyang environmental microorganisms for high active lead compound.