摘要
黄酮类化合物为一大类广泛存在于食物和药物中的天然产物,具有多种药理作用。近来研究表明黄酮类化合物在体内主要以苷元的Ⅱ相代谢产物形式存在,包括不同取代位点的一系列苷元的葡糖醛酸苷、硫酸酯及混合结合物。其中一些Ⅱ相代谢产物已被证明具有抗炎、抗氧化、抗肿瘤、影响代谢酶和转运体等方面的药理活性。文中对文献报道的黄酮、异黄酮、黄酮醇、二氢黄酮、黄烷-3-醇和花色素等黄酮类化合物的Ⅱ相代谢产物及其药理作用进行了综述。
Flavonoids are a large category of natural products present in foods and drugs with diverse pharmacological activities.Recent researches suggest that flavonoids exist in vivo mainly as their phase II metabolites including a series of aglycone glucuronides,sulfates and their mixtures.Some of them have been proved to possess some pharmacological activities like anti-inflammatory,anti-oxidant,and anti-tumor effects and can interact with metabolic enzymes and transporters.This review discusses the previous researches on phase II metabolites of flavonoids include flavones,isoflavones,flavonols,flavonones,flavan-3-ols and anthocyanidins and their pharmacological activities.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2012年第2期144-150,共7页
Chinese Journal of New Drugs
关键词
黄酮类化合物
Ⅱ相代谢产物
药理活性
flavonoids
phase Ⅱ metabolites
pharmacological activities
