同型半胱氨酸和尿酸水平与中老年人冠心病的相关性

The Relationship of Homocysteine and Uric Acid Levels with Coronary Heart Disease in the Middle-aged and Old Patients

目的探讨同型半胱氨酸(HCY)和尿酸(UA)水平与中老年人冠心病的关系。方法将218例患者根据冠脉造影结果分为冠心病组和正常对照组,并根据年龄分为中年冠心病组(61例)和对照组(39例)及老年冠心病组(77例)和对照组(41例),分别采用免疫荧光偏振法和氧化酶法测定血清HCY和UA的水平。结果中年和老年冠心病组血清HCY、UA水平均高于各自对照组,差异均有统计学意义(P<0.01或P<0.05),且中年冠心病组HCY、UA水平均高于老年冠心病组,差异均有统计学意义(P<0.01或P<0.05)。多因素Logistic回归分析显示,HCY、UA是中年冠心病患者的独立危险因素(P<0.01或P<0.05);高血压、糖尿病是老年冠心病患者的独立危险因素(P<0.05)。结论高HCY、高UA是中年人冠心病发生的独立危险因素。

Objective To study the relationship of homocysteine （HCY） and uric acid （UA） level with coronary heart disease （CHD） in the middle-aged and old patients and its clinical significance. Methods According to coronary angiography and their age, 218 patients were divided into middle-aged CHD group （61 cases）, old age CHD group （77 cases） and middle- aged control group （39 cases）, old age control group （41 cases）, and their serum homocysteine and uric acid level were measured by chemiluminescence immunity and oxidase method. Results The serum HCY and UA level of CHD group in middle-age and old age were all higher than those of normal control groups （P〈0.01 or P〈0.05 ）, the serum HCY and UA levels of CHD group in middle age were all higher than those in old-age group （P〈0.01 or P〈0.05）. The Logistic regression analysis demonstrated that HCY and UA were all independent risk factors for CHD in the middle-aged patients （P〈0.01 or P〈0.05）, while hypertension and diabetes mellitus were all independent risk factors for CHD in the old-age patients （P〈0.05）. Conclusion High HCY and high UA level are independent risk factors for CHD in the middle age patients.