基质金属蛋白酶9基因多态性与中国汉族人群冠心病关系的Meta分析

Meta-Analysis of Relationship between Matrix Metalloproteinase-9 Gene 1562C/T Polymorphism and Coronary Heart Disease among Chinese Han Population

目的综合评价基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)基因1562C/T多态性与中国汉族人群冠心病(coronary heart disease,CHD)的关系。方法中文文献以中国学术期刊网(CNKI)全文数据库、重庆维普(VIP)中文科技期刊全文数据库、万方科技期刊全文数据库作为检索数据库,英文文献以Medline、Pubmed、Embase作为检索数据库,检索2011年1月前发表的关于中国汉族人群MMP-9基因1562C/T多态性与CHD关系的病例对照研究文献,应用state11软件进行Meta分析。结果共纳入8篇病例对照研究文献,病例组1661人,对照组1481人。Meta分析表明,中国汉族人群MMP-9基因1562T等位基因与冠心病的发病相关(OR=1.74,95%CI:1.31～2.30)。携带TT基因型的个体发生冠心病的危险性是非TT基因型人群的2.63倍(OR=2.63,95%CI:1.34～5.16)。携带TT基因型的个体发生冠心病的危险性是携带CC基因型个体的2.96倍(OR=2.96,95%CI:1.51～5.79)。敏感性分析显示结果稳定;Begg、Egger检验提示无发表偏倚。结论我国汉族人群MMP-9基因1562C/T多态性与冠心病发病相关,T等位基因可能是冠心病易感性的标记基因之一。

Objective To evaluate the relationship between matrix metalloproteinase-9 （MMP-9） gene 1562C/T polymorphism and coronary heart disease （CHD） among Chinese Han population comprehensively. Methods A literature search based on databases of CNKI, VIP, WanFang, Medline, Pubmed and Embase was made. Literatures that studied the relationship between MMP-9 gene 1562C/T polymorphism and CHD among Chinese Han population and published in English or Chinese full text before January 2011 were included. A comprehensive quantitative analysis was performed by Meta-analysis, using the METAN and METBIAS modules of stata version 11. Results Eight literatures met all study criteria and were selected, with a total of 1 661 cases and 1 481 controls. Meta-analysis suggested that MMP-9 gene T allele was related to coronary heart disease （OR= 1.74, 95%CI ：1.31-2.30）, meanwhile, individuals with TT genotype had a significant increased risk of CHD （OR=2.63, 95%CI： 1.34-5.16） and had 2.96-fold increase in risk for CHD than individuals with CC genotype did. Sensitivity analysis indicated the results were stable. And publication bias was not present, reflected by Pvalues from Egger＇s regression asymmetry test and Begg＇s adjusted rank correction test. Conclusion 1 562C/T polymorphism of MMP-9 gene is associated with CHD. T allele may be one of the susceptibility markers to CHD.