左卡尼汀治疗急性前壁心肌梗死不同时段疗效分析

Effect of L-carnitine on the patients with acute anterior myocardial infarction with different treatment duration

目的评价左卡尼汀辅助治疗急性前壁心肌梗死(AMI)不同时段的疗效。方法将54例急性前壁心肌梗死患者随机分为左卡尼汀治疗组和对照组,治疗组在AMI常规治疗基础上予左卡尼汀静滴10d,而对照组仅为常规治疗。分别于5d和10d后行心脏彩超检查和测定肌钙蛋白I(cTnI)水平。结果治疗组用药10d时心脏彩超和cTnI变化明显优于用药5d时。结论左卡尼汀辅助治疗急性前壁心肌梗死必须达到一定疗程才能发挥作用。

Objective To evaluate the effect of L-carnitine on patients with acute anterior myocardial infarction with different treatment duration. Methods A total of 54 patients with acute anterior myocardial infarction were enrolled in this study and randomly divided into two groups, L-carnitine treatment group and control group. All the patients from both groups received conventional treatment according to guideline for the treatment of AMI. The patients in treatment group received 3 g/d L-carnitine intravenously for ten days. Echocardiography was performed and cardiac tropotin I （cTnI） was measured in both groups after 5 days and 10 days. Results In treatment group, indexes of left ventricular systolic function by echocardiography and the level of cTnI were significantly improved at day 10 compared with those of day 5. Conclusion The effect of longer duration of L-carnitine treatment will be beneficial in the patients with acute anterior myocardial infarction.