左卡尼汀佐治小儿肺炎支原体感染并心肌损害的疗效观察

Clinical Study of the Effect of L-carnitine on Patients with Myocardial Damage Caused by Mycoplasma Pneumoniae

目的:观察左卡尼汀佐治小儿肺炎支原体感染并心肌损害的疗效。方法:将65例肺炎支原体感染并心肌损害的患儿随机分为治疗组32例和对照组33例,对照组予以乳糖酸阿奇霉素10 mg/(kg.d)静脉滴注,3 d为1个疗程,间隔4 d应用第2个疗程,根据病情应用2～3个疗程,同时给予能量合剂及磷酸肌酸钠静脉滴注营养心肌治疗;治疗组加用左卡尼汀100 mg/(kg.d)口服,疗程14 d。结果:治疗后两组心肌酶各项指标均下降(P<0.05),但治疗组心肌酶各项指标恢复情况优于对照组(P<0.05),对照组谷草转氨酶、磷酸肌酸激酶、磷酸肌酸激酶同工酶、乳酸脱氢酶分别为(32.20±5.47)u/L、(129.50±23.11)u/L、(19.03±3.01)u/L、(199.17±15.82)u/L,治疗组分别为(24.17±8.09)u/L、(109.13±24.67)u/L、(16.90±3.27)u/L、(177.03±16.08)u/L;治疗组心电图恢复正常率为88.0%,优于对照组的66.7%(P>0.05)。结论:左卡尼汀治疗肺炎支原体感染并心肌损害有一定疗效。

Objective： To explore the effect of L-carnitine on myocardial damage resulting from mycoplasma pneumoniae（MP）.Methods： Totally 65 patients with MP infection were randomized into the treatment group（32 cases） and the control group（33 cases）.Besides the administration of azithromycin and symptomatic therapy to both groups,the treatment group was also given L-carnitine.Then cardiac enzymes and ECG were measured.Results： The levels of aspartate aminotransferase,phosphocreatine kinase,phosphocreatine kinase isozyme and lactate dehydrogenase were（24.17±8.09） u/L,（109.13±24.67） u/L,（16.90±3.27） u/L,（177.03±16.08） u/L in the treatment group and（32.20±5.47） u/L,（129.50±23.11） u/L,（19.03±3.01） u/L,（199.17±15.82） u/L in the control group.The difference was statistically significant between the two groups after treatment（P〈0.05）.But the difference about the ECG recovery rates between the treatment group（88.0%） and the control group（66.7%） was not statistically significant（P〉0.05）.Conclusions： L-carnitine has a protective effect on the myocardial damage caused by MP.