血必净防治脂肪栓塞综合征30例观察

Xuebijing treatment of fat embolism syndrome in 30 cases

目的观察评价血必净注射液治疗、预防创伤骨折高危患者脂肪栓塞综合征(FES)的临床效果。方法根据治疗方法的不同,将损伤严重评分(ISS)>16分的60例骨折患者随机分为两组,观察组30例采用甲泼尼龙琥珀酸钠加血必净注射液治疗,对照组30例单纯给予甲泼尼龙琥珀酸钠治疗,观察两组患者的ISS评分及FES发病率。结果两组ISS评分差异无统计学意义(P>0.05),但观察组FES发病率明显低于对照组(P<0.05)。结论应用甲泼尼龙琥珀酸钠联合血必净注射液能有效预防创伤骨折高危患者FES的发生。

Objective To observe and evaluate the clinical resuhs of Xuebijing injection therapy, trauma fractures in high risk patients to prevent fat embolism syndrome （FES）. Methods According to the different treatment methods, the injury severity score （ISS） 〉 16 points, 60 cases of fracture were randomly divided into two groups, the obsevation group 30 cases were given methylprednisolone sodium succinate and Xuebijing injection, the control group 30 cases were given methyl- prednisolone sodium succinate alone, the ISS score and the incidence of FES were observed in two groups. Results There were no differences in ISS score significantly （P 〉 0.05）, but the incidence of FES in observation group was significantly lower than that in control group （P 〈 0.05）. Conclusion Methylprednisolone sodium succinate joint Xuebijing injection can be effective in preventing fractures in trauma patients at high risk of occurrence of FES.