基质金属蛋白酶-2在结肠腺癌组织中的表达

The Expression of MMP-2 in Colon Adenocarcinoma Tissues

目的探讨基质金属蛋白酶-2(MMP-2)在结肠腺癌组织中的表达及与临床病理参数之间的关系。方法采用手工组织芯片技术及免疫组织化学技术检测59例结肠腺癌和10例正常结肠组织中MMP-2的表达情况。结果 MMP-2在结肠腺癌组织中的阳性率为62.7%,高于正常结肠组织的20.0%,比较差异有统计学意义(P<0.05)。MMP-2在结肠癌组织中的表达与肿瘤细胞的分化程度、肿瘤大小、浸润深度、淋巴结转移均有关(P<0.05);与患者的年龄无关(P>0.05)。结论 MMP-2高表达对结肠癌的浸润和转移起着重要的作用。

Objective To investigate the expression of matrix metalloproteinase-2（MMP-2） in colon adenocarcinoma tissues and the relationship with the clinicopathological parameters. Methods Immunohistochemistry method and tissue microarray method were used to detect the expression of MMP-2 in 10 cases of colon normal mucosa tissues and 59 cases of colon adenocarcinoma tissues. Results The positive expression rate of MMP-2 in the colon adenocarcinoma（62.7%） was significant higher than that in normal colon mucosa（20.0%）（P0.05）.The expression of MMP-2 in colon adenocarcinoma was related to pathological grade,tumor size,infiltration depth and lymph node metastasis（P0.05）;but had no correlation with age（P0.05）. Conclusion The high expression of MMP-2 is an important factor in the infiltration and metastasis of colon adenocarcinoma.