摘要
目的观察替吉奥治疗晚期胃癌的近期疗效及毒副反应。方法对20例具有可测量指标的晚期胃癌患者采用替吉奥胶囊治疗:替吉奥胶囊80 mg.m-2.d-1,分2次口服,连服14 d,21 d为1周期,连用3周期,休息1个月评价疗效及毒副反应。结果 20例患者中,CR 1例,PR 8例,SD 8例,PD 3例,总有效率45%。主要毒副反应为厌食、恶心、呕吐、皮肤色素沉着、白细胞减少等。结论替吉奥治疗晚期胃癌具有较好疗效,毒副反应轻,特别适宜于年老体弱患者。
Objective To observe the therapeutic effect and toxicities of S-1 capsule in the treatment of advanced gastric cancer. Methods All the 20 cases of advanced gastric cancer with measurable indicators received S-1 capsule treatment： S-1 capsule 80 mg·m-2·d-1,oral,2 times a day for 14 days,21 days were 1 cycle,3 cycles of chemotherapy were given,the therapeutic effect and toxicities were evaluated 1 month after chemotherapy. Results In the 20 cases,CR 1 case,PR 8 cases,SD 8 cases,PD 3 cases,the effective rate was 45%.The major toxicities were anorexia,nausea,vomiting,skin pigmentation and leucopenia. Conclusion S-1 capsule is very effective in the treatment of elderly or frail patients with advanced gastric cancer,and the toxicities can be tolerated.
出处
《肿瘤基础与临床》
2012年第1期24-25,共2页
journal of basic and clinical oncology
关键词
替吉奥
晚期胃癌
疗效
S-1 capsule
advanced gastric cancer
therapeutic effect
