血浆脑钠肽浓度与急性缺血性卒中患者左心室功能的改变的关系

目的观察血浆脑钠肽(BNP)浓度与急性缺血性卒中患者左心室功能的改变的关系。方法 37例急性缺血性卒中患者作为观察组,37例健康体检患者作为对照组,比较两组患者BNP浓度、心功能指标。结果观察组患者心脏每搏输出量、心输出量、心指数和VEF低于对照组;E峰最大速度、A峰最大速度、A及E/A均值与对照组对比,差异有统计学意义(P<0.05)。结论急性缺血性卒中可能会引起患者左心室收缩及舒张功能下降,患者血浆BNP升高也可能与急性缺血性卒中本身病理机制有一定关联。

Objective To observe the relationship between plasma B-type natriuretic peptide（BNP） levels in patients with left ventricular function changes who acute ischemic stroke. Methods Thirty-seven patients with acute ischemic stroke patients was as observation group and 37 healthy subjects as a control group of patients, BNP levels and heart function data of twop groups were compared. Results The CSV, CO, CI and VEF of observation group were all lower than the control group, EPMS, APMS, A and E/A in observation group had all significant difference（P0.05） compared with the control group. Conclusion Acute ischemic stroke patients may lead to decreased left ventricular systolic and diastolic function, elevated plasma BNP may also be associated with acute ischemic stroke associated with certain pathological mechanism itself.