氟西汀联合小剂量奥氮平治疗重度抑郁症的效果分析

目的探讨氟西汀联合小剂量奥氮平治疗重度抑郁症的效果,总结其临床价值。方法选取2009年3月～2011年3月收治的100例经HAMD评分为28分以上的重度抑郁症患者为研究对象,随机分为观察组和对照组,每组各50例,观察组使用氟西汀联合小剂量奥氮平治疗,对照组单纯应用氟西汀治疗,观察比较治疗前和治疗后1、2、4、8周汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)的测定结果及药物不良反应。结果两组治疗前后HAMD、HAMA测定结果比较存在显著差异(P<0.05),观察组降低幅度更为明显(P<0.05),具有统计学意义。两组药物不良反应比较无显著差异(P>0.05),无统计学意义。结论氟西汀联合小剂量奥氮平治疗重度抑郁症的效果显著,明显优于单纯使用氟西汀治疗。

Objective Fluoxetine combined with low dose olanzapine in the treatment of severe depression results, summarized its clinical value. Methods Our hospital from March 2009 to March 2011 100 cases by the HAMD score of 28 points or less severe depression were randomly divided into two groups and the control group, all 50cases, use of fluoxetine combined with small observation group dose of olanzapine in the control group were treated with fluoxetine observed and compared before treatment and after treatment 1,2,4,8 weeks of Hamilton depression scale （HAMD）, Hamilton Anxiety scale （HAMA） in measurement results and adverse drug reactions. Results before and after treatment HAMD, HAMA Comparison of measured were significantly different （P0.05）, lower rate of more obvious observation group （P0.05）, with statistical significance. Two adverse drug reactions showed no significant difference （P 0.05）, not statistically significant. Conclusion Fluoxetine combined with low dose olanzapine in the treatment of severe depression marked effect, significantly better than with fluoxetine treatment.