沙丁胺醇联合布地奈德雾化吸入治疗COPD的临床疗效

Clinical observation on combination effect of salbutamol and Budesonide in treatment of patients with chronic obstructive pulmonary disease

目的观察沙丁胺醇联合布地奈德雾化吸入治疗慢性阻塞性肺病(COPD)的临床疗效。方法将100例COPD患者随机分为观察组和对照组,每组各50例。观察组在常规治疗的基础上观察组予以沙丁胺醇联合布地奈德雾化吸入治疗,对照组仅予以布地奈德雾化吸入治疗。治疗后比较两组血气分析指标、肺功能、总有效率及不良反应情况。结果观察组血气分析指标、肺功能改善及总有效率较对照组明显改善,差异均有统计学意义(P<0.01)。结论沙丁胺醇联合布地奈德雾化吸入治疗COPD较单一用药疗效确切,可提高患者的生活质量,值得临床推广应用。

Objective To study the effect of Salbutamol combined with budesonide in treatment of patients with chronic obstructive pulmonary disease.Methods One hundred patients with COPD were randomly divided into observation group and control group,there were fifty cases in each group.Patients in observation group were treated with combined treatment of Salbutamol and Budesonide besides routine therapeutic regimen,while the patients in control group were treated with conventional therapy of Budesonide,then after the treatment compared and analyzed the indicators blood gas,1ung function,the clinical efficacy and adverse reactions between patients of these two groups.Results The indicators of blood gas,1ung function and the clinical efficacy analysis were compared after the treatment,and their difference was statistically significant（P 0.05）.The diference in corresponding indicators between these two groups was statistically significant（P 0.05）.Conclusion Salbutamol joint with Budesonide was more effective than the application of single drug,and it is an effective choice for treatment of patients with COPD,and it can improve the quality of life of patients and worthy of clinical application..