疏血通注射液与丹参注射液治疗冠心病心绞痛临床研究

Shuxuetong injection and Salvia injection in treating angina pectoris of coronary heart disease

目的探讨疏血通注射液与丹参注射液在缓解冠心病心绞痛症状的治疗效果和临床意义。方法将本院2008年6月～2011年6月心内科186例症状期冠心病患者随机平均分为疏血通组、丹参组、对照组,疏血通组62例患者在常规药物治疗基础上给予6mL疏血通加入250mL5%葡萄糖溶液静脉滴注治疗,每日1次;丹参组62例患者在常规药物治疗基础上给予30mL丹参加入250mL5%葡萄糖溶液静脉滴注治疗,每日1次;对照组62例患者给予常规药物治疗。治疗2周后,比较各组患者心绞痛症状发生次数、持续时间、药物缓解情况以及心电图检查结果。结果 (1)疏血通组、丹参组患者心绞痛症状平均发生次数为(1.1±0.4)、(1.7±0.8)周/次,持续时间为(3.4±1.3)、(4.8±1.5)min,硝酸甘油用量为(0.8±0.6)、(0.9±0.8)片/d,均明显优于对照组心绞痛症状平均发生次数(3.3±1.5)周/次,持续时间(6.1±2.5)min,硝酸甘油用量(1.5±0.9)片/d,差异存在统计学意义(P<0.05)。(2)疏血通组、丹参组患者心电图评价优良率为77.42%、75.80%,明显高于对照组患者心电图评价优良率50.00%,差异存在统计学意义(P<0.05)。结论在常规药物治疗冠心病心绞痛基础上,给予疏血通与丹参静脉滴注能有效缓解患者症状、稳定病情,具有重要的临床治疗价值。

Objective To investigate the Shuxuetong injection and Salvia injection in relieving symptoms of coronary heart disease and clinical significance of treatment effects.Methods The patients in our hospital from June 2008 to June 2011 period of Cardiology 186 cases of coronary heart disease symptoms then were divided into Shuxuetong group,the SM group,the control group,Shuxuetong group of 62 patients treated with conventional therapy based on the given 6 mL Shuxuetong joint 250 mL 5% glucose solution infusion therapy,day 1;Salvia group of 62 patients treated with conventional therapy based on the given 30 mL Salvia joint 250 mL 5% glucose solution infusion therapy,day 1;control group of 62 patients treated with conventional drug treatment.After 2 weeks of treatment,more patients in each group the number of angina symptoms,duration,medication to ease the situation,and ECG were observed.Results（1） SXT group,SM group average of the number of patients with angina were（1.1±0.4）,（1.7±0.8） cycles/time,duration were（3.4±1.3）,（4.8±1.5） min,nitroglycerin consumption were（0.8±0.6）,（0.9±0.8） pieces per day,which were all higher than those of the control groups＇ the average occurrence of angina symptoms（3.3±1.5） cycles/time,duration（6.1±2.5） min,nitroglycerin consumption（1.5±0.9） pieces per day,the differences were statistically significant（P 0.05）.（2） SXT group,ECG evaluation of patients with SM group rate of 77.42% and 75.80%,which was significantly higher in patients with ECG evaluation excellent rate 50.00%,there were statistically significant differences（P 0.05）.Conclusion In the conventional drug treatment of angina pectoris based on the given Shuxuetong with Salvia infusion can effectively relieve symptoms in patients and stable disease has important clinical value.