依达拉奉联合纳洛酮治疗大面积脑梗死的疗效分析

Curative effect of edaravone combined with naloxone on massive cerebral infarction

目的探讨依达拉奉联合纳洛酮治疗大面积脑梗死的临床疗效。方法将77例大面积脑梗死患者随机分为依达拉奉组(A组),依达拉奉30mg每12小时1次静点;联合用药组(B组),除依达拉奉外,联用纳洛酮2.0mg每日1次静点;以及对照组(C组),一般治疗。观察3组的疗效,计算显效率,并加以讨论分析。结果 A组显效率(65.38%)优于C组(36.00%),χ2=4.40;B组(88.46%)优于A组(65.38%),χ2=3.90,差异均有统计学意义(P<0.05)。结论依达拉奉对于大面积脑梗死的治疗具有肯定的疗效,而依达拉奉联用纳洛酮治疗,能够从不同角度取得更佳的治疗效果。

Objective To explore the curative effect of edaravone combined with naloxone on patients with massive cerebral infarction.Methods Seventy seven cases with massive cerebral infarction were randomly divided into group A（with edaravone 30 mg q12h iv drop）,group B（with edaravone combined with naloxone 2.0 mg qd iv drop） and the control group（C）.The curative effect,effective rate,and the results were observed.Results The effective rate in group A（65.38%） was better than that in group C（36.00%）,χ2=4.40,P 0.05,while group B（88.46%） was better than that of group A（65.38%）,χ2=3.90,P 0.05.Conclusion Edaravone is effective in treating patients with massive cerebral infarction,and edaravone combined with naloxone can make a better curative effect.