环磷酰胺联合免疫球蛋白治疗小儿病毒性心肌炎90例疗效观察

An observation on the clinical effect of a combine treament in Cyclophosphamide and immunoglobulin 90 pediatric cases with viral myocarditis

目的探讨环磷酰胺联合免疫球蛋白治疗小儿病毒性心肌炎的临床疗效。方法对90例患儿采用环磷酰胺联合免疫球蛋白治疗,与另外95例单独使用环磷酰胺治疗的患儿进行对照。结果环磷酰胺组患者显效25例,有效20例,无效48例,显效率为26.9%,总有效率为48.4%;联合治疗组患者显效35例,有效38例,无效17例,显效率为38.9%,总有效率为81.1%。两组患者治疗显效率及总有效率差异均有统计学意义(P<0.05),联合治疗组疗效优于环磷酰胺组。结论环磷酰胺联合免疫球蛋白是治疗小儿病毒性心肌炎的一种有效方法。

Objective To explore the clinical effect of the treament which combines Cyclophosphamide and Immunoglobulin to Viral Myocarditis（VM） in child patient.Methods Ninety patients of treament were given combined treament of Cyclophosphamide and immunoglobulin,and compared with 95 patients of the contrast group in which Cyclophosphamide alone was used.Results Among the 93 patients in contrast group,there were 25 patients whose treament found significantly effective,20 cases effective and 48 cases with no any significance.The significantly effective rate was 26.9% and total effective rate was 48.4%;in the control group,35 cases of significant effect,38 cases of effect and 17 cases of no significance.Significantly effective rate was 38.9% and total effective rate was 81.1%.There existed a statistic significance between two groups（P 0.05）.Clinical effect in control group excelled the contrast one.Conclusion The combined treatment of cyclophosphamide and immunoglobulin is a feasible method in tackling VM in child patients.