白三烯动态变化与小儿上呼吸道感染关系研究

Clinical study on leukotrienes in children with upper respiratory tract infection

目的探讨白三烯(LTs)在小儿上呼吸道感染中的变化特征及其意义。方法回顾性分析本院2009年6月～2010年10月收治入院的急性上呼吸道感染患儿46例临床资料,选择本院同期正常体检儿童46例做为对照组。所有患儿分别用双核夹心ELISA法测定急性期及恢复期血、尿白三烯的水平。结果上呼吸道感染患儿在急性期血、尿中白三烯水平显著高于健康儿童,而恢复期与健康儿童差异无统计学意义。上呼吸道感染时白细胞计数大于10×109时显示血、尿LTs水平明显增加,P<0.05。结论白三烯参与上呼吸道感染的发病过程,白三烯受体拮抗剂在上呼吸道感染治疗上可能有一定作用。

Objective To investigate the change character and significance of leukotriene of children with the upper respiratory tract infection.Methods The clinical data of 46 cases of children with acute upper respiratory tract infection in our hospital in June 2009 to October 2010 was analyzed,46 cases of normal children were chosen as control group.Blood and urine leukotriene level of them were detected with dual-core sandwich ELISA method in the acute and recovery phase.Results Blood,urine leukotriene level of children in the acute phase was significantly higher than healthy children,and that of recovery phase and healthy children has no significant differences.Blood and urine LTs level increased obviously when white blood count was more than 10×109,P 0.05.Conclusion Leukotriene participates in the process of the upper respiratory tract infection,leukotriene receptor antagonists may have had some effect in the upper respiratory tract infection treatment.