他克莫司软膏治疗糜烂型口腔扁平苔藓的效果观察

Clinical observation of therapeutic effect of Tacrolimus Ointment in the treatment of patients with erosive oral lichen planus

目的:观察他克莫司软膏局部用药治疗糜烂型口腔扁平苔藓的疗效。方法:选择2009年6月～2011年1月在我科就诊的患者共62例,将其随机分成A组(应用他克莫司软膏局部涂擦)和B组(应用卤米松乳膏局部涂擦),疗程8周。结果:用药2个月后,A组有效率为90.3%,B组有效率为64.5%;停药6个月后治疗组复发率为9.1%,对照组复发率为60.0%。两组比较差异均有统计学意义(均P<0.05)。结论:他克莫司软膏局部涂抹治疗糜烂型口腔扁平苔藓具有良好的临床疗效。

Objective： To evaluate the efficacy of Tacrolimus Ointment in the treatment of patients with erosive oral lichen planus.Methods： 62 patients in our department of our hospital were divided into two groups（group A and B）.Group A was treated with Tacrolimus Ointment and group B was treated with Halometasone Ointment,the time was 8 weeks in a randomized clinical trial.Results： After treatment of 2 months,in the group A and B,the efficacy rate was 90.3%,64.5% respectively,and the relapse rate within 6 months after treatment was 9.1% and 60.0% respectively,there were significant differences in the two groups（all P0.05）.Conclusion： The results of the present work demonstrate that Tacrolimus Ointment is an effective therapy for oral lichen planus.