五种中药静脉注射液与输液配伍前后不溶性微粒变化的研究

Changes of insoluble particles in five kinds of traditional Chinese medicine injections mixed with infusion solution

目的:考察5种中药静脉注射液与葡萄糖大输液配伍后不溶性微粒数量的变化。方法:用微粒分析仪分别测定配伍前输液(5%葡萄糖注射液)及其与中药注射液(血塞通注射液、银杏达莫注射液、红花注射液、参附注射液、香丹注射液)配伍后的微粒数目,并考察配伍后不同时间测得的微粒数目。结果:输液与中药注射液配伍后不溶性微粒数显著多于配伍前(P<0.05)。结论:输液与中药注射液配伍后微粒数目明显增多,在临床应用中应重视此现象,尽量避免不良反应的发生。

Objective： To study the changes of the insoluble particles in glucose injection（5%） and in the glucose injections mixed with five different Chinese herbal intravenous injections.Methods： The numbers of insoluble particles in glucose injection（5%） and in the glucose injections mixed with five different Chinese herbal intravenous injections were counted.And the numbers of insoluble particles in the five injections at different time were investigated.Results： The numbers of insoluble particles obviously increased after combination（P0.05）.Conclusions： The increase of insoluble particles in these five Chinese herbal intravenous injections may be focused during clinical use.So the adverse reactions can avoid as far as possible.