蓝光照射对高胆红素血症新生儿免疫系统的影响

Study of blue light therapy's effects on newborn's immune system with hyperbilirubinemia

目的探讨蓝光照射治疗对高胆红素血症新生儿免疫系统的影响。方法对2008年1月-2010年1月我科诊治的45例高胆红素血症新生儿进行蓝光照射治疗,比较患儿治疗前后血常规、淋巴细胞亚群及NK细胞的差异。结果高胆红素血症新生儿光照治疗前血总胆红素为（291.5±42.8）μmol/L,治疗后为（214.2±33.9）μmol/L,治疗后的血清总胆红素浓度低于治疗前（P〈0.05）。患儿治疗后血常规中白细胞和淋巴细胞较治疗前显著增加（P〈0.001）,红细胞和血红蛋白显著降低（P〈0.001）,而血小板无明显差异（P〉0.05）。治疗后,高胆红素血症新生儿的淋巴细胞亚群CD35^＋、CD3^＋、CD4^＋、CD8^＋和CD4^＋/CD8^＋及NK细胞均升高,高于治疗前百分比,差异均有高度统计学意义（均P〈0.001）。结论蓝光照射治疗可改善胆红素对高胆红素血症新生儿免疫系统的损伤,显著提高患儿免疫力。

Objective To study blue light therapy＇s effects on newborn＇s immune system with hyperbilirubinemia.Methods 45 newborns with hyperbilirubinemia in our department from January 2008 to January 2010 were treated with blue light.The before and after therapy blood routines,lymphocyte subsets and NK cell were compared.Results The total bilirubin after blue light therapy was significantly higher than before therapy [（291.5±42.8） μmol/L vs（214.2±33.9） μmol/L]（P〈0.05）.White blood cells and lymphocytes increased,while red blood cells and hemoglobin decreased（P〈0.001）,but platelet showed no difference（P〈0.05）.The lymphocyte subsets such as CD35^＋,CD3^＋,CD4^＋,CD8^＋,CD4^＋/CD8^＋ and NK cells increased after therapy,they were significantly higher than before therapy（all P〈0.001）.Conclusion Blue light therapy can reverse hyperbilirubinemia＇s inhibition effect on newborn＇s immune system,which can significantly increase the immunity.