含左氧氟沙星三联疗法治疗幽门螺杆菌阳性残胃炎的疗效观察

Efficacy of Levofloxacin-based triple therapy in patients with remnant gastritis of Helicobacter pylori infection

目的评价含左氧氟沙星三联疗法治疗幽门螺杆菌(Helicobacter pylori,Hp)阳性残胃炎患者的疗效。方法将35例Hp阳性的残胃炎患者随机分为两组,治疗组给予埃索美拉唑20 mg/次,阿莫西林1 000 mg/次,左氧氟沙星200 mg/次,均为2次/d,连服7 d。对照组给予埃索美拉唑20 mg/次,阿莫西林1 000 mg/次,甲硝唑400 mg/次,均为2次/d,连服7 d。治疗前及停药4周后观察临床症状改善情况、Hp清除率,并通过胃镜检查比较残胃黏膜炎症变化。结果治疗组治疗后总有效率为88.89%,较对照组(64.71%)显著提高;Hp清除率治疗组为94.44%,对照组为70.59%,差异有统计学意义(P<0.05);且两组症状积分、残胃黏膜炎症活动度差异均有统计学意义(均P<0.05)。结论含左氧氟沙星三联疗法对Hp阳性残胃炎患者Hp根除效果明显好于标准三联疗法,Hp根除后临床症状可显著改善。

Objective To observe the therapeutic effects of Levofloxacin-based triple therapy in patients with remnant gastrits of Helicobacter pylori（Hp） infection.Methods 35 patients with remnant gastrits of Hp infection were randomly divided into 2 groups.18 cases of treated group were taken Esomeprazole 20 mg bid,Amoxicillin 1 000 mg bid,Levofloxacin 200 mg bid,for 7 days;17 cases of control group were taken Esomeprazole 20 mg bid,Amoxicillin 1 000 mg bid,Metronidazole 400 mg bid,for 7 days.The mend matters of clinical symptoms and Hp eradication rates before treatment and after treatment for 4 weeks were compared between the two groups,and the inflammation changes of gastric remnant mucous membrane were compared through gastroscope.Results The total effective rate of treatment group was 88.89%,significantly higher than the control group（84.71%）,the Hp eradication rate was 94.44% in the treatment group and 70.59% in the control group,and there were significant differences between the two groups（P〈0.05）.The differences of symptom scores and the inflammation mobility of gastric remnant mucous membrane between the two groups were significant（P〈0.05）.Conclusion The Levofloxacin-based triple therapy has a better effect for remnant gastrits patients in Hp eradication than standard triple therapy and the symptoms can be significantly improved after Hp eradication.