酪氨酸激酶B与VEGF在涎腺腺样囊性癌中的表达及其与侵袭转移相关性的分析

An analysis of metastasis and perineural invasion correlated with the expressions of TrKB and VEGF in salivary gland adenoid cystic carcinoma

目的:通过检测酪氨酸激酶B(TrkB)及血管内皮生长因子(VEGF)在涎腺腺样囊性癌(SACC)的表达情况,探讨TrkB和VEGF在SACC侵袭转移中的作用及两者相关关系。方法:采用免疫组织化学S-P法检测47例SACC患者组织病理切片中TrkB和VEGF的表达情况,结合临床资料统计分析,评价TrkB,VEGF在SACC侵袭转移中的作用及两者的相关性。结果:TrkB,VEGF在SACC组织中的阳性率分别是89.36%(42/47例)和85.1%(40/47例),在有神经侵袭、转移及实性型SACC患者组织切片中TrkB和VEGF的表达率均高于无神经侵袭、转移及腺样管状型者,且差别有统计学意义(P<0.05);TrkB和VEGF的表达率成正相关关系(P<0.01)。结论:TrkB,VEGF的表达强弱与SACC的嗜神经侵袭,血行转移能力成正相关关系,表明两者在SACC的侵袭转移过程中具有重要的作用,且TrkB和VEGF的表达呈正相关关系,并由此推测TrkB可以作为抗血管治疗SACC的潜在的靶向目标。

Objective:To determine the effect of tyrosine kinase B(TrkB) and vascular endothelial growth factor(VEGF) in the invasion and metastasis of SACC(salivary gland adenoid cystic carcinoma).Investigate the correlation between both of them.Method:The expression of TrkB and VEGF were detected by immunohistochemical staining in 47 cases of ACC of salivary glands.Clinical data were reviewed by multivariate prognostic analysis.Result:The positive rate of TrkB and VEGF in SACC was 89.36 %(42/47) and 85.1 %(40/47) respectively.Express of TrkB and VEGF in perineural invasion,recurrence and solid-type group were higher than non-perineural invasion,non-recurrence and tubular type group.Significant relationship was found in TrkB and VEGF expression,P <0.05.Positive correlation between expression of TrkB and VEGF(P <0.01).Conclusion:The clinic pathological and Kaplan-Meier Survival analysis of this group indicate that TrkB and VEGF play important roles in the invasion and metastasis of SACC.It is possible that TrkB may represent a potential target for antiangiogenic therapy in SACC.