血清胱抑素C对帕金森病的临床诊断价值

Clinical Value of Serum Cystatin C on Parkinson's Disease

目的:探讨血清胱抑素C(CysC)对帕金森病(PD)的临床诊断意义,为帕金森病的早期诊断和预防治疗提供可参考的血清学指标。方法:采用日立7170全自动生化分析仪检测53例帕金森病患者的血清CysC,以33例健康人作为对照,采用SPSS13.0软件对数据进行统计分析。结果:PD组CysC平均水平为(1.18±0.37)mg/mL,健康对照组为(0.79±0.15)mg/mL,组间均数有显著性差异(t=6.663,P=0.000<0.05)。诊断PD的ROC曲线下的面积为0.860,面积下95%可信区间为(0.782±0.938)。在ROC曲线上确定诊断界点,当界点为0.938时,灵敏度为0.755,特异度为0.888;当界点为1.030时,灵敏度为0.528,特异度为0.970。当CysC水平>0.938 mg/mL时,PD组阳性率为75.47%;当CysC水平>1.03 mg/mL时,PD组阳性率为52.83%。结论:血清CysC对PD的诊断有一定的意义,CysC水平越高,确诊为PD的可能性越大;CysC水平>0.938 mg/mL时,能很好地区别于健康对照组。

Objective： To investigate the clinical value of serum cystatin C（CysC） on Parkinson＇s disease（PD） in order to provide a reference on early diagnosis and prophylaxis of PD.Methods： Serum CysC of 53 patients with PD were detected by Hitachi 7170 automatic biochemical analyzer,and 33 health persons as control group.All the data was analyzed by SPSS13.0.Results： The mean level of serum CysC of PD group was（1.18±0.37）mg/mL and the control group＇s was（0.79±0.15）mg/mL with significant difference（t=6.663,P=0.0000.05）.The area under the ROC curve diagnosed in PD group was 0.860 with（0.782±0.938） of 95% CI.When the cut point was 0.938,the sensitivity was 0.755,and the specificity was 0.888.When the cut point was 1.030,the sensitivity was 0.528 and the specificity was 0.970 which divided by the ROC curve.When the level of CysC was more than 0.938 mg/mL,the positive rate was 75.47%,while the level of CysC was more than 1.03 mg/mL,the positive rate was 52.83%.Conclusion： Serum CysC can help to diagnosis PD.The higher CysC level is the more possibility was.When the CysC0.938 mg/mL,we can distinguish health people with a balanced sensitiveness and specificity.