乙酰胆碱酯酶分子研究进展

Research Progresses of the Acetylcholinestrase Molecules

乙酰胆碱酯酶是生物体内胆碱能神经传导中的一种关键酶,它能够快速水解神经递质乙酰胆碱,保证神经信号在生物体内正常传递。乙酰胆碱酯酶结构和催化功能研究一直是生命科学的重要课题,可为研制有针对性的新药和杀虫剂提供重要理论依据。我们简要介绍了乙酰胆碱酯酶的三维晶体结构、活性位点、高效催化机制及其应用。

Acetylcholinestrase（AChE） is one of the key enzymes in cholinergic nervous system.One of the neurotransmitters named acetylcholine can be hydrolyzed rapidly by AChE.The study on the structure and catalytic functions of AChE is one important issue in life sciences.In this paper,the crystal structure,the active sites,the efficient catalytic mechanism and the applications of acetylcholinestrase are reviewed.