半乳凝素-3在宫颈上皮内瘤变及宫颈鳞状细胞癌中的表达及其意义

Expression and Clinical Significance of Galectin-3 in Cervical Intraepithelial Neoplasia and Cervical Squamous Cell Carcinoma

目的:探讨半乳凝素-3(Galectin-3)在宫颈上皮内瘤变(CIN)及宫颈鳞状细胞癌(SCC)中的表达及其意义。方法:选择经病理确诊为CIN和SCC患者的石蜡标本60例,以同时期因子宫肌瘤行全子宫切除患者的正常宫颈组织(NC)石蜡标本10例作为对照,采用免疫组化方法分析CIN及SCC中Galectin-3表达情况。结果:NC、CIN、SCC及SCCⅠ、SCCⅡ、SCCⅢ组Galectin-3表达阳性率分别为40.00%、50.00%、83.33%及70.00%、90.00%、90.00%。NC、CIN、SCC3组间Galectin-3表达阳性率差异有统计学意义(χ2=9.559,P=0.049);NC组Galectin-3表达阳性率与SCCⅡ期组及Ⅲ期组比较,差异有统计学意义(χ2=5.495,P=0.029)。宫颈肿瘤>2cm组Galectin-3表达阳性率高于≤2cm组,差异有统计学意义(χ2=4.690,P=0.047)。结论:SCC中Galectin-3的阳性表达与肿瘤大小有关;Galectin-3表达阳性率随宫颈病变发展而升高。Galectin-3可能在SCC的发生、进展中发挥作用。

Objective：To investigate the expression and role of Galectin-3 in cervical intraepithelial neoplasia（CIN） and squamous cell carcinoma（SCC）.Methods：60 paraffin samples with CIN and SCC diagnosed by pathology were selected,and 10 cases of normal cervical（NC） tissue taken from hysterectomy uterus because of leiomyoma were as control.The expression of Galectin-3 in CIN and SCC were detected by immunohistochemistry.Results：In NC,CIN,SCC and SCC stage Ⅰ-Ⅲ,the positive expression rate of Galectin-3 were 40.00%、50.00%、83.33%、70.00%、90.00% and 90.00% respectively.There was significant difference of positive expression rate of Galectin-3 in NC、CIN and SCC group（χ2=9.559,P =0.049）.The positive expression rate of Galectin-3 in SCC stage Ⅱ and Ⅲ were significantly greater than that in NC group（χ2=5.495,P=0.029）.There was statistical difference of Galectin-3 expression between tumor sizes more than 2 cm and less than 2 cm（χ2=4.690,P=0.047）.Conclusions：The positive Galectin-3 expression in SCC is associated with tumor sizes,but is no relationship with tumor differentiation.The positive expression rate of Galectin-3 is high with progression of cervical lesions.Galectin-3 may play some important roles in the occurrence and progression of SCC.