肝脏局灶性结节性增生的临床诊治分析

Analysis on diagnosis and treatment of focal nodular hyperplasia of liver

目的探讨肝脏局灶结节性增生的临床特点、治疗及预后。方法对2001～2011年徐州医学院附属医院收治并经病理证实的7例FNH的临床资料进行回顾性分析。结果本组共7例患者,男2例,女5例,该病多见于中青年,40岁以下者5例,占71.4%,多无明显临床症状。HBsAg阳性者1例,占14.3%,肝功能和甲胎蛋白检查均正常。病灶多为单发,直径平均为(3.8±2.1)cm。7例均行手术切除。所有患者随访1～5年全部存活。结论 FNH是一种肝脏良性增生性病变,术前不易确诊,手术切除是有效的治疗方法,预后良好。

Objective To study the clinical features,treatment and prognosis of focal nodular hyperplasia of liver. Methods The clinical data of 7 patients with FNH treated and confirmed by pathology diagnosis from 2001 to 2011 in the affiliated hospital of Xuzhou medical college were analyzed retrospectively. Results Among the 7 patients,2 were males,5 were females,the disease is more common in young and middle-aged people. 5（71.4%）patients were below 40 years old,6 were asymptomatic. Hepatitis B was negative in 1（14.3%）of patients. Liver function and AFP are all normal. FNH occurs as a single node in 6 patients ,average diameter is （3.8 ± 2.1）cm. All the cases were performed operation and followed up for 1 year to 5 years without death. Conclusion FNH is a kind of benign proliferative lesion of the liver,but it is hard to diagnose before the operation. Surgical resection is the effective cure for treatment,the prognosis is good.