脑脉泰胶囊对急性脑梗死TGF-β、IL-1β及TNF-α的影响

The Effect of Naomaitai Capsule on TGF-β,IL-1β and TNF-α of the Patients with Acute Cerebral Infarction

目的:观察脑脉泰胶囊治疗急性脑梗死患者(ACI)的临床疗效及对转化生长因子β(TGF-β)、白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)的影响。方法:64例ACI患者随机分为:对照组、治疗组,每组32例,均给予常规治疗,治疗组加用脑脉泰胶囊,每日3次,每次2粒,疗程为2周,比较治疗前后神经功能缺损(NIHSS)评分及各指标的变化。结果:治疗后两组各指标比较差异均具有统计学意义(P<0.05)。结论:脑脉泰胶囊能减少炎症细胞因子表达、改善脑血流灌注,明显控制脑梗死的进展及复发。

Objective To observe the effect of Naomaitai Capsule on TGF-β,IL-1β and TNF-α of the patients with acute cerebral infarction（ACI）.Methods 60 cases with ACI were randomly divided into 2 groups：treatment group and control group,32 cases in each;routine treatment was given to patients in both groups while Naomaitai Capsule was added to patients in treatment group,3 times a day,2 capsules once;the course lasted for 2 weeks;NIHSS scores and other index before and after treatment were compared.Result The comparison of various index of the 2 groups after treatment was of statistical difference（P0.05）.Conclusions Naomaitai Capsule can decrease the expression of inflammatory cytokines,improve brain perfusion and obviously control the progress and reoccurrence of cerebral infarction.