“疯草”中苦马豆素解毒制剂及抗肿瘤应用研究进展

Research Advances in the Detoxificating Preparation of Swainsonine in "Locoweed" and Its Application to Anti-tumor

"疯草"中的主要毒性成分苦马豆素,属于一种多羟基取代吲哚兹定生物碱。其能抑制动物机体中的α-甘露糖苷酶,造成人和动物中毒;同时又具有极强的抗肿瘤活性,而对人有益。全文概述了苦马豆素的生化特性、中毒机理、解毒制剂研制以及抗肿瘤作用的研究进展,以期为预防治疗苦马豆素中毒以及合理开发利用苦马豆素提供参考。

Swainsonine was the main toxic component of ＂locoweed＂,and belonged to polyhydroxyl-substituted indolizidine alkaloid.Swainsonine could inhibit α-mannosidase in animal body and poison both human and animals;it also had strong anti-tumor activity which was beneficial to human beings.The paper introduced the research advances in the biochemical characteristics,poisoning mechanism,detoxification preparation and anti-tumor function of swainsonine,aiming to provide references for preventing and curing swainsonine poisoning and rationally developing swainsonine.